| First Author | Leatherman JL | Year | 2000 |
| Journal | Mech Dev | Volume | 92 |
| Issue | 2 | Pages | 145-53 |
| PubMed ID | 10727854 | Mgi Jnum | J:61448 |
| Mgi Id | MGI:1354999 | Doi | 10.1016/s0925-4773(99)00335-4 |
| Citation | Leatherman JL, et al. (2000) Identification of a mouse germ cell-less homologue with conserved activity in Drosophila. Mech Dev 92(2):145-53 |
| abstractText | Drosophila Germ cell-less (Gcl) has previously been shown to be important in early events during the formation of pole cells, which are the germ cell precursors in the fly. We have isolated a 524 amino acid mouse gene with 32% identity and 49% similarity to Drosophila gcl, termed mgcl-1. Like Drosophila Gcl, mGcl-1 localizes to the nuclear envelope. Ectopic expression of mgcl-1 in Drosophila rescues the gcl-null phenotype, indicating that mGcl-1 is a functional homologue of Gcl. mgcl-1 maps to chromosome 6 at 47.3 cM, and is expressed at low levels at all embryonic stages examined from 8.5 to 18.5 d.p.c. as well as in many adult tissues. Different from Drosophila gcl, mgcl-1 is not highly expressed at the time the primordial germ cells appear in the mouse, but high mgcl-1 expression is found in selected mouse adult male germ cells. The differences in these expression patterns in light of conserved activity between the two genes is discussed. |
