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Protein Coding Gene : Gopc golgi associated PDZ and coiled-coil motif containing
Primary Identifier  MGI:2149946 Organism  mouse, laboratory
Chromosome  10 NCBI Gene Number  94221
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0)

Enables GTPase regulator activity; frizzled binding activity; and protein homodimerization activity. Acts upstream of or within spermatid nucleus differentiation. Located in Golgi apparatus; plasma membrane; and synapse. Is expressed in genitourinary system and tongue. Used to study azoospermia. Orthologous to human GOPC (golgi associated PDZ and coiled-coil motif containing).
PHENOTYPE: Mice homozygous for a null allele show male sterility with globozoospermia characterized by a complete lack of acrosomes due to failure of vesicle transport from the Golgi apparatus, a malformed sperm nucleus, and abnormal mitochondrial arrangement in the mitochondrial sheath of mutant spermatozoa. [provided by MGI curators]
  • synonyms:
  • MGI:2143681,
  • AI844555,
  • GOPC1,
  • expressed sequence AI844555,
  • RIKEN cDNA 2210402P09 gene,
  • golgi associated PDZ and coiled-coil motif containing,
  • 2210402P09Rik,
  • Gopc,
  • MGI:1913757
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Features --> Cross References

Genome

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2 Involved In Mutations

Trail: ProteinCodingGene

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0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

7 Pathways

Trail: ProteinCodingGene

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Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

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