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Publication : Mouse deoxyribonuclease I (DNase I): biochemical and immunological characterization, cDNA structure and tissue distribution.

First Author  Takeshita H Year  1997
Journal  Biochem Mol Biol Int Volume  42
Issue  1 Pages  65-75
PubMed ID  9192086 Mgi Jnum  J:41312
Mgi Id  MGI:893737 Doi  10.1080/15216549700202441
Citation  Takeshita H, et al. (1997) Mouse deoxyribonuclease I (DNase I): biochemical and immunological characterization, cDNA structure and tissue distribution. Biochem Mol Biol Int 42(1):65-75
abstractText  Mouse urinary deoxyribonuclease I (DNase I) resembles rat and human DNase Is in terms of its proteochemical and enzymological properties. Furthermore, mouse DNase I was demonstrated to be immunologically closer to the rat than to the human enzyme. A 1176 bp full length cDNA encoding mouse DNase I was constructed from RNA obtained from the kidney and parotid glands. The amino acid sequence up to the 45th residue from the N-terminal of the mature enzyme was identical to that deduced from the cDNA sequence. This DNase I was distributed most densely in the parotid glands from the standpoint of both enzyme activity and gene transcript levels.
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