| Primary Identifier | MGI:106441 | Organism | mouse, laboratory |
| Chromosome | 7 | NCBI Gene Number | 360216 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Predicted to enable K63-linked polyubiquitin modification-dependent protein binding activity and cysteine-type deubiquitinase activity. Predicted to be involved in several processes, including cytoskeleton organization; positive regulation of Wnt signaling pathway; and regulation of cell morphogenesis. Predicted to act upstream of or within Wnt signaling pathway and proteolysis. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including brain; extraembryonic component; genitourinary system; and neural retina. Orthologous to human ZRANB1 (zinc finger RANBP2-type containing 1). PHENOTYPE: Homozygous knock-out allele leads to decreased CD4+ T cells and decreased susceptibility to experimental autoimmune encephalomyelitis. Homozygous enzymatic inactivation leads to reduced colon mucosa thickness and increased morbidity and mortality after DSS-induced colitis. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
