| Primary Identifier | MGI:1338073 | Organism | mouse, laboratory |
| Chromosome | 16 | NCBI Gene Number | 12544 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to enable DNA replication origin binding activity; chromatin binding activity; and single-stranded DNA binding activity. Predicted to be involved in DNA metabolic process. Predicted to act upstream of or within DNA replication. Predicted to be located in centrosome; ciliary basal body; and nucleoplasm. Predicted to be part of CMG complex. Is expressed in several structures, including alimentary system; branchial arch; cardiovascular system; central nervous system; and notochord. Human ortholog(s) of this gene implicated in Meier-Gorlin syndrome 7. Orthologous to human CDC45 (cell division cycle 45). PHENOTYPE: Homozygous mutant embryos do not develop after implantation, resulting in embryonic lethality between E4.5-E5.5. Heterozygous animals appear normal and fertile. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
