| First Author | Chatterjee J | Year | 2021 |
| Journal | Nat Commun | Volume | 12 |
| Issue | 1 | Pages | 7122 |
| PubMed ID | 34880260 | Mgi Jnum | J:316881 |
| Mgi Id | MGI:6842792 | Doi | 10.1038/s41467-021-27455-6 |
| Citation | Chatterjee J, et al. (2021) Asthma reduces glioma formation by T cell decorin-mediated inhibition of microglia. Nat Commun 12(1):7122 |
| abstractText | To elucidate the mechanisms underlying the reduced incidence of brain tumors in children with Neurofibromatosis type 1 (NF1) and asthma, we leverage Nf1 optic pathway glioma (Nf1(OPG)) mice, human and mouse RNAseq data, and two different experimental asthma models. Following ovalbumin or house dust mite asthma induction at 4-6 weeks of age (WOA), Nf1(OPG) mouse optic nerve volumes and proliferation are decreased at 12 and 24 WOA, indicating no tumor development. This inhibition is accompanied by reduced expression of the microglia-produced optic glioma mitogen, Ccl5. Human and murine T cell transcriptome analyses reveal that inhibition of microglia Ccl5 production results from increased T cell expression of decorin, which blocks Ccl4-mediated microglia Ccl5 expression through reduced microglia NFkappaB signaling. Decorin or NFkappaB inhibitor treatment of Nf1(OPG) mice at 4-6 WOA inhibits tumor formation at 12 WOA, thus establishing a potential mechanistic etiology for the attenuated glioma incidence observed in children with asthma. |
