| First Author | Solimini NL | Year | 2007 |
| Journal | Cell | Volume | 130 |
| Issue | 6 | Pages | 986-8 |
| PubMed ID | 17889643 | Mgi Jnum | J:129997 |
| Mgi Id | MGI:3770559 | Doi | 10.1016/j.cell.2007.09.007 |
| Citation | Solimini NL, et al. (2007) Non-oncogene addiction and the stress phenotype of cancer cells. Cell 130(6):986-8 |
| abstractText | Heat-shock factor 1 (HSF1) is a transcription factor that is activated upon proteotoxic stress and coordinates induction of the heat-shock response. In this issue, Dai et al. (2007) show that HSF1 is a potent modifier of tumorigenesis and is required for tumor initiation and maintenance in a variety of cancer models. These findings add HSF1 to a growing list of non-oncogenes that could be exploited as cancer drug targets. |
