| First Author | Seo JY | Year | 2021 |
| Journal | Nat Commun | Volume | 12 |
| Issue | 1 | Pages | 1294 |
| PubMed ID | 33637766 | Mgi Jnum | J:304854 |
| Mgi Id | MGI:6515124 | Doi | 10.1038/s41467-021-21621-6 |
| Citation | Seo JY, et al. (2021) Maintenance of type 2 glycolytic myofibers with age by Mib1-Actn3 axis. Nat Commun 12(1):1294 |
| abstractText | Age-associated muscle atrophy is a debilitating condition associated with loss of muscle mass and function with age that contributes to limitation of mobility and locomotion. However, the underlying mechanisms of how intrinsic muscle changes with age are largely unknown. Here we report that, with age, Mind bomb-1 (Mib1) plays important role in skeletal muscle maintenance via proteasomal degradation-dependent regulation of alpha-actinin 3 (Actn3). The disruption of Mib1 in myofibers (Mib1(DeltaMF)) results in alteration of type 2 glycolytic myofibers, muscle atrophy, impaired muscle function, and Actn3 accumulation. After chronic exercise, Mib1(DeltaMF) mice show muscle atrophy even at young age. However, when Actn3 level is downregulated, chronic exercise-induced muscle atrophy is ameliorated. Importantly, the Mib1 and Actn3 levels show clinical relevance in human skeletal muscles accompanied by decrease in skeletal muscle function with age. Together, these findings reveal the significance of the Mib1-Actn3 axis in skeletal muscle maintenance with age and suggest the therapeutic potential for the treatment or amelioration of age-related muscle atrophy. |
