First Author | Janßen L | Year | 2016 |
Journal | J Cell Sci | Volume | 129 |
Issue | 1 | Pages | 219-27 |
PubMed ID | 26527401 | Mgi Jnum | J:234528 |
Mgi Id | MGI:5790164 | Doi | 10.1242/jcs.175620 |
Citation | Janssen L, et al. (2016) The murine cytomegalovirus immunoevasin gp40 binds MHC class I molecules to retain them in the early secretory pathway. J Cell Sci 129(1):219-27 |
abstractText | In the presence of the murine cytomegalovirus (mCMV) gp40 (m152) protein, murine major histocompatibility complex (MHC) class I molecules do not reach the cell surface but are retained in an early compartment of the secretory pathway. We find that gp40 does not impair the folding or high-affinity peptide binding of the class I molecules but binds to them, leading to their retention in the endoplasmic reticulum (ER), the ER-Golgi intermediate compartment (ERGIC) and the cis-Golgi, most likely by retrieval from the cis-Golgi to the ER. We identify a sequence in gp40 that is required for both its own retention in the early secretory pathway and for that of class I molecules. |