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Protein Coding Gene : Dock5 dedicator of cytokinesis 5
Primary Identifier  MGI:2652871 Organism  mouse, laboratory
Chromosome  14 NCBI Gene Number  68813
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0)

Enables guanyl-nucleotide exchange factor activity. Involved in Rac protein signal transduction. Acts upstream of or within bone remodeling and podosome assembly. Located in cytoplasm and podosome. Is expressed in several structures, including genitourinary system; hemolymphoid system gland; liver; lung; and myotome. Orthologous to human DOCK5 (dedicator of cytokinesis 5).
PHENOTYPE: Mutations at this locus result in lens abnormalities involving cataracts and rupturing of the lens nucleus. [provided by MGI curators]
  • synonyms:
  • MGI:2145709,
  • AI666732,
  • expressed sequence AI666732,
  • MGD-MRK-36554,
  • MGI:107974,
  • MGI:1101762,
  • BC016533,
  • MGC:28003,
  • dedicator of cytokinesis 5,
  • lr2,
  • rupture of lens cataract,
  • lens rupture 2,
  • RIKEN cDNA 1110060D06 gene,
  • 1110060D06Rik,
  • expressed sequence AI956923,
  • MGI:2145688,
  • rlc,
  • cDNA sequence BC016533,
  • MGI:1916063,
  • Dock5,
  • AI956923
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1 Involved In Mutations

Trail: ProteinCodingGene

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Trail: ProteinCodingGene

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