Primary Identifier | MGI:2445707 | Allele Type | Transgenic |
Attribute String | Transactivator | Gene | Tg(Scgb1a1-rtTA)1Jaw |
Strain of Origin | 129 and C57BL/6 | Is Recombinase | false |
Is Wild Type | false |
description | Phenotypic Similarity to Human Syndrome: Bronchopulmonary dysplasia (J:130523, J:171488). |
molecularNote | The transgene is composed of 2.3 kb of rat Ugb (Scgb1a1) promoter, a reverse tetracycline responsive transactivator gene (rt-TA), and 2 kb of human growth hormone sequences, which includes introns and a polyadenylation signal. Transgene expression was confirmed by RT-PCR analysis. The rat Scgb1a1 promoter is active in respiratory epithelial cells. |