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Comment :

Type  disruption phenotype Description  Mild metabolic effects (PubMed:29664675, PubMed:30431159). Mice grow normally and glucose metabolism in male or female mice is normal (PubMed:29664675). Minimal metabolic effects are observed: female mice display a minor decrease in fat accumulation when fed Western diet and have a lower respiratory exchange ratio when fed chow diet (PubMed:29664675). Mice also exhibit a subtle phenotype in response to lipopolysaccharide administration, characterized by slight changes in the metabolome associated with glycolysis (PubMed:30431159).