| Primary Identifier | IPR015031 | Type | Domain |
| Short Name | Capsid_VP4_Picornavir |
| description | This entry represents the VP4 coat protein found in Picornaviruses, small RNA-containing mammalian viruses such as Foot-and-mouth disease virus (FMDV) [], Mengo encephalomyocarditis virus []and Theiler's murine encephalomyelitis virus (strain DA) (TMEV) []. The viral capsid of Picornaviruses is composed of 60 icosahedral copies of four capsid proteins, VP1, VP2, VP3 and VP4, enclosing the viral positive-strand RNA genome. VP4 lies on the inner surface of the protein shell formed by the major capsid proteins, VP1, VP2 and VP3. The three major capsid proteins have a conserved β-barrel fold, while VP4 has little regular secondary structure. The organisation of the three major capsid proteins leads to surface depressions, or pits, thought to be involved in receptor binding, while the variable outer rim is involved in antibody recognition. The small VP4 is thought to be involved in the initial disassembly and final assembly stages []. |
