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Allele : Sorl1<tm1Tew> sortilin-related receptor, LDLR class A repeats-containing; targeted mutation 1, Thomas E Willnow

Primary Identifier  MGI:3604352 Allele Type  Targeted
Attribute String  Null/knockout Gene  Sorl1
Transmission  Germline Strain of Origin  Not Specified
Is Recombinase  false Is Wild Type  false
molecularNote  A neomycin resistance cassette replaced exon 4 sequence downstream of nucleotide 583 (serine 195). Full length protein was not detected in brain homogenates from homozygous mice. A truncated form of the protein that is 162 bps shorter and lacks 54 residues within the N-terminal region of the VPS10p domain is detected at low levels in brain lysates from homozygous and heterozygous mice.
  • mutations:
  • Intragenic deletion,
  • Insertion
  • synonyms:
  • sorLA<->,
  • LR11<deltaEx4>,
  • LR11<deltaEx4>,
  • sorLA<->
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

0 Carried By

0 Driven By

24 Publication categories

Trail: Allele