| First Author | Larhammar D | Year | 1983 |
| Journal | Cell | Volume | 34 |
| Issue | 1 | Pages | 179-88 |
| PubMed ID | 6411350 | Mgi Jnum | J:34455 |
| Mgi Id | MGI:81912 | Doi | 10.1016/0092-8674(83)90148-4 |
| Citation | Larhammar D, et al. (1983) Structure of the murine immune response I-A beta locus: sequence of the I-A beta gene and an adjacent beta-chain second domain exon. Cell 34(1):179-88 |
| abstractText | The murine major histocompatibility complex I region encodes two class II antigens, I-A and I-E. From a mouse spleen DNA cosmid library of the b haplotype, we isolated a clone containing the entire I-A beta gene and a separate exon encoding a beta-chain second domain (A beta 2). The A beta gene, encompassing more than 6 kb, is encoded by six exons corresponding to the different domains of the A beta polypeptide. The translated A beta amino acid sequence displays 73% homology to human DC beta chains; homologies to other subsets of human beta chains are lower, establishing that I-A corresponds structurally to DC. The A beta 2 exon is about 20 kb centromeric to the A beta gene. Its translated amino acid sequence includes all the conserved amino acids of other class II beta-chain second domains. It shows about 60% homology to each of three subsets of human beta chains available for comparison, and to the A beta chain. No A beta 2 first domain exon has been detected with A beta or DC beta probes. |
