| First Author | Kim HJ | Year | 1998 |
| Journal | J Biochem | Volume | 124 |
| Issue | 2 | Pages | 451-6 |
| PubMed ID | 9685741 | Mgi Jnum | J:70296 |
| Mgi Id | MGI:2136753 | Doi | 10.1093/oxfordjournals.jbchem.a022134 |
| Citation | Kim HJ, et al. (1998) Evolution of the apolipoprotein E receptor 2 gene by exon loss. J Biochem 124(2):451-6 |
| abstractText | The apolipoprotein E receptor 2 (apoER2) gene consists of a mosaic of exons, which may have been assembled by 'exon shuffling.' Analysis of apoER2 transcripts in several species reveals a lost repeat in the ligand-binding domain of primate apoER2. A pseudo-exon found in the primate apoER2 genes corresponds to the lost repeat but contains a crucial deletion that leads to a translational frameshift. The pseudo-exon sequence in primary transcripts of the human apoER2 gene is shown to be abolished by exon skipping due to two nucleotide substitutions at the 5'-splice donor adjacent to the pseudo-exon. These data suggest the occurrence of exon loss in the evolution of the primate apoER2 gene. |
