| First Author | Mizuta TR | Year | 1993 |
| Journal | Nucleic Acids Res | Volume | 21 |
| Issue | 8 | Pages | 1761-6 |
| PubMed ID | 8493094 | Mgi Jnum | J:4973 |
| Mgi Id | MGI:53452 | Doi | 10.1093/nar/21.8.1761 |
| Citation | Mizuta TR, et al. (1993) Isolation of cDNA encoding a binding protein specific to 5'-phosphorylated single-stranded DNA with G-rich sequences. Nucleic Acids Res 21(8):1761-6 |
| abstractText | We have isolated the cDNA encoding a binding protein to the sequence motif of the immunoglobulin S mu region by the southwestern method. The binding protein designated S mu bp-2 specifically binds to 5'-phosphorylated single-stranded DNA containing 5'-G and GGGG stretches. The amino acid sequence deduced from the cDNA sequence showed that the S mu bp-2 belongs to the putative helicase superfamily which is involved in replication, recombination and repair. Expression of S mu bp-2 mRNA is ubiquitous and augmented in spleen cells stimulated with lipopolysaccharide and interleukin 4 which also induce class switching. The S mu bp-2 gene is conserved among vertebrates. Possible involvement of S mu bp-2 in class switching is discussed. |
