| Primary Identifier | IPR020366 | Type | Family |
| Short Name | Ies5 |
| description | The INO80 complex is involved in chromatin-remodelling by promoting the repositioning (sliding) or eviction of nucleosomes from the DNA in an ATP-dependent process. The INO80 chromatin-remodelling complex of Saccharomyces cerevisiae (Baker's yeast) is composed of at least 15 subunits and has a molecular mass of about 1.2 to 1.5 MDa. In S. cerevisiae the core conserved subunits are: ATPase; Ino80.RuvB-like; Rvb1 and Rvb2.Actin; Act1.Actin-related: Arp4, Arp5 and Arp8.YEATS protein []; Taf14.The non-conserved subunits are: Ies1, Ies2, Ies3, Ies4, Ies5, Ies6 and Nhp10 []. The Ino80 ATPase is a member of the SNF2 family of ATPases and functions as an integral component of a multisubunit ATP-dependent chromatin remodelling complex that is conserved from yeast to mammals. Although INO80 complexes from yeast and higher eukaryotes share a common core of conserved subunits, the complexes have diverged substantially during evolution and have acquired new subunits with apparently species-specific functions. Studies in S. cerevisiae have shown that the conserved HSA (helicase) domain of the ATPase subunit, Ino80, is required for the binding of the Arp's and Act1, and this conserved module links the chromatin-remodelling complex to itssubstrate, the nucleosome [, ]. In eukaryotes the chromatin-remodelling complexes such as the SWR1 and INO80 complexes have many crucial functions including the control of gene regulation and expression, checkpoint regulation, DNA replication and repair, telomer maintenance and chromosomal segregation and as such represent critical components of pathways that maintain genomic integrity [, , ].This entry represents the INO80 subunit 5 or Ies5, which has been shown to associate with the INO80 chromatin-remodelling complex under low-salt conditions [], though its function is unknown. |
