| Primary Identifier | IPR026081 | Type | Family |
| Short Name | DISC1 |
| description | Disrupted-In-Schizophrenia 1 (DISC1) was identified as a novel gene disrupted by a (1;11)(q42.1;q14.3) translocation segregating with schizophrenia, bipolar disorder and other major mental illnesses in a Scottish family [, ]. Human DISC1 is multifunctional with several interacting proteins, including components of the dynein motor protein complex, such as nuclear distribution element-like (NDEL1/NUDEL) and lissencephaly 1 protein (LIS1). DISC1 is also required for regulation of microtubule dynamics, neurite outgrowth and neuronal migration in vivo []. |
