| First Author | Tamakoshi T | Year | 2006 |
| Journal | Biochem Biophys Res Commun | Volume | 339 |
| Issue | 3 | Pages | 932-8 |
| PubMed ID | 16325766 | Mgi Jnum | J:104135 |
| Mgi Id | MGI:3611173 | Doi | 10.1016/j.bbrc.2005.11.097 |
| Citation | Tamakoshi T, et al. (2006) Roles of the Foxj1 and Inv genes in the left-right determination of internal organs in mice. Biochem Biophys Res Commun 339(3):932-8 |
| abstractText | In Foxj1 knockout mice, half show situs solitus while the other half show situs inversus, which means a random determination of the left-right axis. In contrast, the inv mutant mice show a mirror-image configuration of the internal organs, which means a reversal of the left-right axis. Although these two mutant mice have primary cilia on the nodal cells, their phenotypes are different in laterality determination. We thus made Foxj1/inv double mutant mice and analyzed their phenotype. We found the phenotypes of Foxj1/inv double mutant mice to be more similar to those of the Foxj1 mutant mice than those of the inv mutant mice. We also found right pulmonary isomerism to be a major phenotype of the Foxj1 mutant mice and the Foxj1/inv double mutant mice, which is likely due to the absence of the Pitx2 expression at both lateral plate mesoderms. These results indicate that a random signal of laterality (Foxj1) is dominant over the reversal signal of laterality (Inv). |
