| First Author | Inlay MA | Year | 2009 |
| Journal | Genes Dev | Volume | 23 |
| Issue | 20 | Pages | 2376-81 |
| PubMed ID | 19833765 | Mgi Jnum | J:154864 |
| Mgi Id | MGI:4410397 | Doi | 10.1101/gad.1836009 |
| Citation | Inlay MA, et al. (2009) Ly6d marks the earliest stage of B-cell specification and identifies the branchpoint between B-cell and T-cell development. Genes Dev 23(20):2376-81 |
| abstractText | Common lymphoid progenitors (CLPs) clonally produce both B- and T-cell lineages, but have little myeloid potential in vivo. However, some studies claim that the upstream lymphoid-primed multipotent progenitor (LMPP) is the thymic seeding population, and suggest that CLPs are primarily B-cell-restricted. To identify surface proteins that distinguish functional CLPs from B-cell progenitors, we used a new computational method of Mining Developmentally Regulated Genes (MiDReG). We identified Ly6d, which divides CLPs into two distinct populations: one that retains full in vivo lymphoid potential and produces more thymocytes at early timepoints than LMPP, and another that behaves essentially as a B-cell progenitor. |
