| First Author | Simon PD | Year | 1999 |
| Journal | Brain Res Dev Brain Res | Volume | 117 |
| Issue | 2 | Pages | 219-23 |
| PubMed ID | 10567740 | Mgi Jnum | J:58593 |
| Mgi Id | MGI:1349255 | Doi | 10.1016/s0165-3806(99)00123-6 |
| Citation | Simon PD, et al. (1999) Thy-1 is critical for normal retinal development. Brain Res Dev Brain Res 117(2):219-23 |
| abstractText | In the mammalian retina, Thy-1, the most abundant mammalian neuronal surface glycoprotein, is found predominantly if not exclusively on retinal ganglion cells. We hypothesized that Thy-1 plays a significant role in retinal development. Neurite outgrowth of retinal ganglion cells from Thy-1(-) mice over multiple substrates was compared to that seen with wild-type controls. Adult mouse retinas were histologically compared between Thy-1(-) and three strains of Thy-1 positive mice. Thy-1(-) retinal ganglion cells had significantly less neurite outgrowth than controls. The inner nuclear, inner plexiform, ganglion cell and outer segment/pigment epithelium layers were thinner in Thy-1(-) retinae than in controls. Thy-1 appears to be critical for normal retinal development. |
