| First Author | Bernard C | Year | 2022 |
| Journal | Science | Volume | 378 |
| Issue | 6622 | Pages | eabm7466 |
| PubMed ID | 36423280 | Mgi Jnum | J:331924 |
| Mgi Id | MGI:7407370 | Doi | 10.1126/science.abm7466 |
| Citation | Bernard C, et al. (2022) Cortical wiring by synapse type-specific control of local protein synthesis. Science 378(6622):eabm7466 |
| abstractText | Neurons use local protein synthesis to support their morphological complexity, which requires independent control across multiple subcellular compartments up to the level of individual synapses. We identify a signaling pathway that regulates the local synthesis of proteins required to form excitatory synapses on parvalbumin-expressing (PV(+)) interneurons in the mouse cerebral cortex. This process involves regulation of the TSC subunit 2 (Tsc2) by the Erb-B2 receptor tyrosine kinase 4 (ErbB4), which enables local control of messenger RNA mRNA translation in a cell type-specific and synapse type-specific manner. Ribosome-associated mRNA profiling reveals a molecular program of synaptic proteins downstream of ErbB4 signaling required to form excitatory inputs on PV(+) interneurons. Thus, specific connections use local protein synthesis to control synapse formation in the nervous system. |
