| Primary Identifier | IPR011696 | Type | Family |
| Short Name | Huwentoxin-1 |
| description | This is a family of potent toxins that function as ion-channel inhibitors. Omega-Grammotoxin SIA is a VSCC antagonist that inhibits neuronal N- and P-type VSCC responses []. Huwentoxin-IV, from the Chinese bird spider, is a highly potent neurotoxin that specifically inhibits the neuronal tetrodotoxin-sensitive voltage-gated sodium channel in rat dorsal root ganglion neurons []. Hainantoxin-4, from the venom of spider Selenocosmia hainana, adopts an inhibitor cystine knot structural motif like huwentoin-IV, and is a potent antagonist that acts at site 1 on tetrodotoxin-sensitive (TTX-S) sodium channels []. Study of the molecular nature of toxin-receptor interactions has helped elucidate the functioning of many ion-channels []. Some members of this family, Tap1 and Tap2, can modulate the activity of both voltage-gated sodium and calcium channels which are implicated in the etiology of chronic pain, being interesting for chronic pain treatment [, ]. |
