| First Author | Reolon GK | Year | 2006 |
| Journal | Brain Res | Volume | 1076 |
| Issue | 1 | Pages | 225-30 |
| PubMed ID | 16473336 | Mgi Jnum | J:107064 |
| Mgi Id | MGI:3620261 | Doi | 10.1016/j.brainres.2006.01.008 |
| Citation | Reolon GK, et al. (2006) Long-term memory for aversive training is impaired in Idua(-/-) mice, a genetic model of mucopolysaccharidosis type I. Brain Res 1076(1):225-230 |
| abstractText | Mucopolysaccharidosis type I (MPS I) is a lysosomal storage disease that leads to neurodegeneration and neurological deficits, among other pathological and clinical consequences. The aim of the present study was to evaluate neurobehavioral parameters in a genetic mouse model of mucopolysaccharidosis type I (MPS I). During exploration of an open field, adult MPS I (Idua(-/-)) mice showed normal locomotion and anxiety but reduced number of rearings. Idua(-/-) mice performed normally in a novel object recognition memory task and showed normal short-term retention of inhibitory avoidance training. By contrast, long-term retention of inhibitory avoidance was impaired in Idua(-/-) mice. The deficit in inhibitory avoidance memory could not be attributed to reduced footshock reactivity. The results indicate that Idua(-/-) mice present deficits in long-term memory for aversive training and reduced exploratory behavior. |
