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Publication : Aquaporin-9 is expressed in a mucus-secreting goblet cell subset in the small intestine.

First Author  Okada S Year  2003
Journal  FEBS Lett Volume  540
Issue  1-3 Pages  157-62
PubMed ID  12681500 Mgi Jnum  J:82733
Mgi Id  MGI:2654971 Doi  10.1016/s0014-5793(03)00256-4
Citation  Okada S, et al. (2003) Aquaporin-9 is expressed in a mucus-secreting goblet cell subset in the small intestine. FEBS Lett 540(1-3):157-62
abstractText  We analyzed the expression of aquaporins (AQPs) in the small intestine to elucidate their functions, and found that AQP9, which had not previously been detected there, is present in duodenum, jejunum, and ileum. AQP9 is expressed in colon as well, but not in stomach. Also, its expression in these intestinal sections is limited to the basolateral membranes of a goblet cell subset. Our finding that AQP9 is present specifically in goblet cells as mucus-secreting cells suggests its involvement in the synthesis and/or secretion of a certain kind of mucus which may protect the intestinal surface and smooth the flow of intestinal contents.
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