Primary Identifier | MGI:1202882 | Organism | mouse, laboratory |
Chromosome | 4 | NCBI Gene Number | 19746 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to enable ammonium transmembrane transporter activity. Acts upstream of or within ammonium transmembrane transport; erythrocyte development; and multicellular organismal-level iron ion homeostasis. Located in membrane. Is expressed in several structures, including gonad; heart; liver; lung; and spleen. Human ortholog(s) of this gene implicated in Rh isoimmunization. Orthologous to human RHCE (Rh blood group CcEe antigens) and RHD (Rh blood group D antigen). PHENOTYPE: Mice homozygous for a knock-out allele exhibit decreased ammonium and methylammonium transport in red cell ghosts, reduced basal adhesion of red blood cells to endothelial cells, and a slight increase in iron levels. [provided by MGI curators] |