| First Author | Merrell K | Year | 1995 |
| Journal | Mamm Genome | Volume | 6 |
| Issue | 4 | Pages | 291-4 |
| PubMed ID | 7613037 | Mgi Jnum | J:24380 |
| Mgi Id | MGI:72146 | Doi | 10.1007/BF00352419 |
| Citation | Merrell K, et al. (1995) Genetic analyses of tattered, an X-linked dominant, developmental mouse mutation. Mamm Genome 6(4):291-4 |
| abstractText | Tattered (Td) is an X-linked dominant mouse mutation that causes prenatal lethality in affected males. To map the locus, we analyzed 199 normal male and affected female progeny from a backcross of Td and Mus castaneus. Pedigree analysis of these animals suggests a gene order of cen-DXWas70-(Td, DXMit26, Gata1, Tcfe3)-(Cybb, Otc)-tel, where Tcfe3 is a transcription factor homologous to a gene involved in the murine microphthalmia (mi) mutation [Hodgkinson et al. Cell 74, 395-404, 1993]. To evaluate Tcfe3 as a candidate for Td, heterozygous tattered females were crossed to xid males to obtain females in which > 95% of B cells expressed genes solely from the Td X Chromosome (Chr). Fluorescent activated cell sorting (FACS) analysis and Western blotting of isolated splenocytes from Td/xid double heterozygotes rule out Tcfe3 as a likely candidate for the Td mutation. |
