| First Author | Li J | Year | 2012 |
| Journal | FEBS Lett | Volume | 586 |
| Issue | 4 | Pages | 448-54 |
| PubMed ID | 22289179 | Mgi Jnum | J:181914 |
| Mgi Id | MGI:5314429 | Doi | 10.1016/j.febslet.2012.01.028 |
| Citation | Li J, et al. (2012) Transcription-independent role of Bach1 in mitosis through a nuclear exporter Crm1-dependent mechanism. FEBS Lett 586(4):448-54 |
| abstractText | The transcriptional repressor Bach1 mediates various stress responses. Despite its role in transcription, Bach1 is predominantly exported to the cytoplasm in a Crm1-dependent manner, but the functional role of its cytoplasmic retention is still unclear. We found that Bach1 was also excluded from mitotic chromatin by a C-terminal cytoplasmic localization sequence dependent and leptomycin B sensitive process. Bach1 depletion resulted in disordered mitotic chromosome alignment, which was rescued by Bach1 mutants lacking the BTB or DNA binding domains, suggesting its transcription-independent mechanism. We thus revealed a novel role of Bach1 in the regulation of mitotic chromosome dynamics. |
