| First Author | Nakajima A | Year | 2003 |
| Journal | Cancer Lett | Volume | 201 |
| Issue | 2 | Pages | 195-201 |
| PubMed ID | 14607334 | Mgi Jnum | J:100301 |
| Mgi Id | MGI:3587805 | Doi | 10.1016/s0304-3835(03)00443-9 |
| Citation | Nakajima A, et al. (2003) BRPK, a novel protein kinase showing increased expression in mouse cancer cell lines with higher metastatic potential. Cancer Lett 201(2):195-201 |
| abstractText | A novel protein kinase named BRPK was isolated and partially characterized. BRPK was expressed at a higher level in three carcinoma cell lines with higher metastatic potential. Mouse and human BRPK cDNAs are well conserved and encode 580 and 581 amino acids, respectively. BRPK has a serine/threonine-type protein kinase domain, and the recombinant proteins of BRPK were capable of autophosphorylation. The results of a comparative sequence analysis indicated a possible link of BRPK to BRAP2. BRAP2 is known to bind the nuclear localization signal of BRCA1. We cloned mouse BRAP2 cDNA and showed the presence of isoforms. |
