| First Author | Dale RM | Year | 2007 |
| Journal | Biochem Biophys Res Commun | Volume | 357 |
| Issue | 3 | Pages | 683-7 |
| PubMed ID | 17445768 | Mgi Jnum | J:121803 |
| Mgi Id | MGI:3711633 | Doi | 10.1016/j.bbrc.2007.04.008 |
| Citation | Dale RM, et al. (2007) An alternative transcript of the FOG-2 gene encodes a FOG-2 isoform lacking the FOG repression motif. Biochem Biophys Res Commun 357(3):683-7 |
| abstractText | The FOG family of transcriptional co-factors is composed of two members in mammals: FOG-1 and FOG-2. Both have been shown to bind to GATA factors and function as transcriptional co-repressors in specific cell and promoter contexts. We have previously defined a novel repression domain localized to the N-terminus of each FOG family member, the FOG repression motif, which is necessary for FOG-mediated transcriptional repression. In this report, we describe the identification and characterization of a novel isoform of FOG-2 lacking the FOG repression motif. In contrast to full-length FOG-2, this isoform is expressed predominately in the embryonic and adult heart. It can bind GATA4 avidly, but is unable to repress GATA4-mediated activation of cardiac-restricted gene promoters. Together, these results suggest that FOG-2 repressive activity may be modulated by the generation of isoforms of FOG-2 lacking the FOG repression motif. |
