| First Author | Mi QS | Year | 2006 |
| Journal | Nat Med | Volume | 12 |
| Issue | 6 | Pages | 624-6 |
| PubMed ID | 16732280 | Mgi Jnum | J:109554 |
| Mgi Id | MGI:3629273 | Doi | 10.1038/nm1424 |
| Citation | Mi QS, et al. (2006) The autoimmune regulator (Aire) controls iNKT cell development and maturation. [RETRACTED: Nat Med 2006; 12:1100]. Nat Med 12(6):624-626 |
| abstractText | The mechanism underlying the autoimmune polyglandular syndrome type-1 (APS1) has been attributed to defective T-cell negative selection resulting from reduced expression and presentation of autoantigens in thymic medullary epithelial cells (MECs). It has also been postulated that Aire is involved in development of regulatory T cells, although supporting evidence is lacking. Here we show that expression of Aire in MECs is required for development of iNKT cells, suggesting a role for iNKT cells in APS1. |
