| First Author | Perkins KJ | Year | 2003 |
| Journal | FEBS Lett | Volume | 538 |
| Issue | 1-3 | Pages | 168-72 |
| PubMed ID | 12633873 | Mgi Jnum | J:82290 |
| Mgi Id | MGI:2651997 | Doi | 10.1016/s0014-5793(03)00175-3 |
| Citation | Perkins KJ, et al. (2003) Ets, Ap-1 and GATA factor families regulate the utrophin B promoter: potential regulatory mechanisms for endothelial-specific expression. FEBS Lett 538(1-3):168-72 |
| abstractText | Duchenne muscular dystrophy is caused by dystrophin deficiency, which can be prevented in the mdx mouse model by over-expression of an autosomal homologue, utrophin. Utrophin has two characterised full-length promoters, A and B. No data are available on the transcriptional regulation of B utrophin, which has been recently localised to the endothelium. Similar to characterised endothelial promoters, Ets and Ap-1 individually trans-activate the human B core promoter. Synergistic activation by GATA-2 and c-jun to the order of 20-fold was observed. |
