| First Author | Könner AC | Year | 2011 |
| Journal | Cell Metab | Volume | 13 |
| Issue | 6 | Pages | 720-8 |
| PubMed ID | 21641553 | Mgi Jnum | J:176085 |
| Mgi Id | MGI:5288294 | Doi | 10.1016/j.cmet.2011.03.021 |
| Citation | Konner AC, et al. (2011) Role for insulin signaling in catecholaminergic neurons in control of energy homeostasis. Cell Metab 13(6):720-8 |
| abstractText | Dopaminergic midbrain neurons integrate signals on food palatability and food-associated reward into the complex control of energy homeostasis. To define the role of insulin receptor (IR) signaling in this circuitry, we inactivated IR signaling in tyrosine hydroxylase (Th)-expressing cells of mice (IR(DeltaTh)). IR inactivation in Th-expressing cells of mice resulted in increased body weight, increased fat mass, and hyperphagia. While insulin acutely stimulated firing frequency in 50% of dopaminergic VTA/SN neurons, this response was abolished in IR(DeltaTh) mice. Moreover, these mice exhibited an altered response to cocaine under food-restricted conditions. Taken together, these data provide in vivo evidence for a critical role of insulin signaling in catecholaminergic neurons to control food intake and energy homeostasis. |
