| First Author | Chapman VM | Year | 1975 |
| Journal | Biochem Genet | Volume | 13 |
| Issue | 11-12 | Pages | 849-56 |
| PubMed ID | 1200981 | Mgi Jnum | J:5600 |
| Mgi Id | MGI:54077 | Doi | 10.1007/BF00484415 |
| Citation | Chapman VM (1975) 6-Phosphogluconate dehydrogenase (PGD) genetics in the mouse: linkage with metabolically related enzyme loci. Biochem Genet 13(11-12):849-56 |
| abstractText | An electrophoretic polymorphism of 6-phosphogluconate dehydrogenase (PGD) has been observed in the subspecies Mus musculus musculus from northern Denmark. M. m. musculus is interfertile with inbred strains of mice, and F1 hybrids with C57BL/6J show a three-banded phenotype. This pattern is consistent with a dimeric enzyme structure with codominant expression of alleles. In backcrosses and the F2 generation, PGD segregated as a singly autosomal gene, designated Pgd, closely linked to Gpd-1 on chromosome 4(1.7 +/- 1.1%). Both gene products are dimers, both require NADP, and these enzymes catalyze sequential steps in metabolism. |
