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Protein Domain : Protein male-specific lethal-1, dimerisation domain

Primary Identifier  IPR031840 Type  Domain
Short Name  MSL1_dimer
description  This entry represents the short coiled dimerisation domain of higher eukaryotic MSL1, part of the MSL or Male-Specific Lethal complex. This complex regulates the dosage compensation of the male X chromosome in Drosophila and other eukaryotes. The structure of the MSL1/MSL2 core shows that two MSL2 subunits bind to a dimer formed by two molecules of MSL1. MSL1 is a substrate for MSL2 E3 ubiquitin ligase activity [].

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1 Protein Domain Regions