Primary Identifier | MGI:1923041 | Organism | mouse, laboratory |
Chromosome | 5 | NCBI Gene Number | 231672 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to enable ubiquitin protein ligase activity. Predicted to contribute to ubiquitin-protein transferase activity. Involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process and protein ubiquitination. Acts upstream of or within labyrinthine layer blood vessel development and spongiotrophoblast layer development. Part of Cul7-RING ubiquitin ligase complex and SCF ubiquitin ligase complex. Is expressed in several structures, including heart; liver; lung; placenta; and spleen. Orthologous to human FBXW8 (F-box and WD repeat domain containing 8). PHENOTYPE: Mice homozygous for a null allele display partial late embryonic lethality with embryonic growth retardation and abnormal placental morphology. [provided by MGI curators] |