| First Author | Jansson L | Year | 1989 |
| Journal | J Reprod Immunol | Volume | 15 |
| Issue | 2 | Pages | 141-50 |
| PubMed ID | 2769647 | Mgi Jnum | J:27613 |
| Mgi Id | MGI:75102 | Doi | 10.1016/0165-0378(89)90033-8 |
| Citation | Jansson L, et al. (1989) Oestrogen induced suppression of collagen arthritis. IV: Progesterone alone does not affect the course of arthritis but enhances the oestrogen-mediated therapeutic effect. J Reprod Immunol 15(2):141-50 |
| abstractText | The effects of 17 beta-oestradiol and progesterone on the development of type II collagen-induced arthritis (CIA) and the anti-type II collagen (CII) autoantibody response were investigated. Treatment with physiological doses of 17 beta-oestradiol, inducing serum levels below the estradiol peak at the end of pregnancy, abrogated the development of arthritis and suppressed the anti-CII autoantibody response. Treatment with progesterone alone did not have significant effects on the development of arthritis or on the anti-CII autoantibody response. However, a combined treatment with both progesterone and oestrogen in physiological doses induced a more pronounced suppression of CIA than the suppression induced with oestrogen treatment alone. These findings suggest that oestrogen, but not progesterone, may be the critical factor to explain the pregnancy-related down-regulation of CIA. |
