| First Author | Lapveteläinen T | Year | 1995 |
| Journal | Anat Rec | Volume | 242 |
| Issue | 2 | Pages | 159-65 |
| PubMed ID | 7668400 | Mgi Jnum | J:25747 |
| Mgi Id | MGI:73462 | Doi | 10.1002/ar.1092420204 |
| Citation | Lapvetelainen T, et al. (1995) Lifelong moderate running training increases the incidence and severity of osteoarthritis in the knee joint of C57BL mice. Anat Rec 242(2):159-65 |
| abstractText | BACKGROUND: Inbred C57BL male mice express a high incidence of spontaneous osteoarthritis of the knee joint at the age of 18 months. We used this strain of mice to find out the effects of life-long, moderate running exercise on the health of articular cartilage and the incidence of osteoarthritis. METHODS: Male mice (294) were divided into controls and runners. The runners were trained daily between 2 and 18 months of age. The speed was 13.3 m/min and the distance on a flatbelt treadmill was 1,000 m/day. The mice were sacrificed at the ages of 2, 6, 10, 14, and 18 months. The knee joints were sectioned in frontal direction and the osteoarthritic changes were graded using a conventional light microscope. The reproducibility of the grading method was tested by calculating the extended kappa-coefficient for the results of six researchers. RESULTS: The incidence of osteoarthritis at the age of 18 months increased from 72% in controls to 88% in runners in the medial tibial condyles (P < 0.05), and from 80 to 96% in the lateral tibial condyles (P < 0.001). The incidence of the most severe osteoarthritic changes rose from 16% in controls to 36% in runners in the medial tibial condyles, and from 4 to 36% in the lateral tibial condyles. CONCLUSION: According to our results, the moderate, long-lasting running exercise accelerates the development of osteoarthritis in the knee joints of C57BL mice. |
