| First Author | Quirion MR | Year | 2009 |
| Journal | J Immunol | Volume | 182 |
| Issue | 2 | Pages | 741-5 |
| PubMed ID | 19124715 | Mgi Jnum | J:143503 |
| Mgi Id | MGI:3827046 | Doi | 10.4049/jimmunol.182.2.741 |
| Citation | Quirion MR, et al. (2009) Cutting edge: Ikaros is a regulator of Th2 cell differentiation. J Immunol 182(2):741-5 |
| abstractText | Ikaros, a hematopoietic transcription factor, has well defined effects on early lymphocyte development in the bone marrow and thymus. In this study we demonstrate that Ikaros is a positive regulator of Th2 cytokine gene expression in peripheral T cells. CD4+ T cells from naive Ikarosnull mice cultured under Th2-skewing conditions express the Th1 cytokine IFN-gamma and have reduced IL-4, IL-5, and IL-13 expression. Ikaros directly associates with several Th2 locus regulatory regions in naive CD4+ T cells. The decreased ability to express Th2 cytokines in Ikarosnull T cells corresponds with histone 3 hypoacetylation across the Th2 cytokine locus as well as decreased GATA3 and cMaf and increased T-bet and STAT1 expression. These data support a model whereby Ikaros directly activates Th2 gene expression by promoting local chromatin accessibility during CD4+ T cell differentiation and also acts indirectly to regulate expression of Th2- and Th1-specific transcription factors. |
