| First Author | Shackleford GM | Year | 1987 |
| Journal | Cell | Volume | 50 |
| Issue | 1 | Pages | 89-95 |
| PubMed ID | 3594566 | Mgi Jnum | J:178219 |
| Mgi Id | MGI:5297689 | Doi | 10.1016/0092-8674(87)90665-9 |
| Citation | Shackleford GM, et al. (1987) Expression of the proto-oncogene int-1 is restricted to postmeiotic male germ cells and the neural tube of mid-gestational embryos. Cell 50(1):89-95 |
| abstractText | The int-1 proto-oncogene is transcriptionally activated in mammary tumors by mouse mammary tumor virus insertion mutations and is normally expressed only in adult mouse testes and mid-gestational embryos. We have used anatomical dissection of embryos, germ-cell fractionation, peripuberal expression studies, and spermatogenesis mutants to identify more precisely the tissues and cells that contain int-1 RNA. In the testis, int-1 RNA is detected only in postmeiotic germ cells undergoing differentiation from round spermatids into mature spermatozoa. In embryos 11-15 days after conception, expression of the gene is restricted to the developing central nervous system in regions of the neural tube other than the telencephalon. Our findings suggest that int-1 mediates developmental events at these two sites. |
