| Primary Identifier | MGI:1195256 | Organism | mouse, laboratory |
| Chromosome | 1 | NCBI Gene Number | 18783 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.4.0) Enables calcium-dependent phospholipase A2 activity. Involved in several processes, including arachidonate secretion; glycerophospholipid metabolic process; and icosanoid biosynthetic process. Acts upstream of or within several processes, including cellular response to antibiotic; icosanoid biosynthetic process; and positive regulation of prostaglandin secretion. Located in Golgi apparatus; cytosol; and endoplasmic reticulum. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; respiratory system; and sensory organ. Orthologous to human PLA2G4A (phospholipase A2 group IVA). PHENOTYPE: Mice homozygouse for disruptions in this gene display reduced allergic and autoimmune reactions. They also display an increased incidence of insulin and reduced female reproductive performance. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
