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Protein Coding Gene : Mettl21c methyltransferase 21C, AARS1 lysine

Primary Identifier  MGI:3611450 Organism  mouse, laboratory
Chromosome  1 NCBI Gene Number  433294
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0)

Enables protein-lysine N-methyltransferase activity. Acts upstream of or within cellular response to hormone stimulus; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; and skeletal muscle tissue development. Predicted to be located in cytoplasm and nucleus. Predicted to be part of protein-containing complex. Predicted to be active in cytosol. Is expressed in alimentary system; diaphragm; genitourinary system; skeletal muscle; and skin. Orthologous to human METTL21C (methyltransferase 21C, AARS1 lysine).
PHENOTYPE: Mice homozygous for a knock-out allele exhibit muscle weakness, impaired exercise endurance, dysregulated autophagy during denervation-induced muscle atrophy, and reduced ATPase activity in skeletal muscle. [provided by MGI curators]
  • synonyms:
  • methyltransferase 21C, AARS1 lysine,
  • Mettl21c,
  • RIKEN cDNA A530098C11 gene,
  • A530098C11Rik

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1 Involved In Mutations

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Canonical gene --> Transcripts in specific strains.

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