| First Author | Fujiwara H | Year | 2008 |
| Journal | Biochem Biophys Res Commun | Volume | 369 |
| Issue | 2 | Pages | 432-6 |
| PubMed ID | 18291100 | Mgi Jnum | J:134174 |
| Mgi Id | MGI:3785098 | Doi | 10.1016/j.bbrc.2008.02.043 |
| Citation | Fujiwara H, et al. (2008) Transient infiltration of neutrophils into the thymus following whole-body X-ray irradiation in IL-10 knockout mice. Biochem Biophys Res Commun 369(2):432-6 |
| abstractText | IL-10 is known to suppress the inflammatory responses in a variety of experimental models. Because we previously found that whole-body X-irradiation causes massive apoptosis in the thymus and transient infiltration of neutrophils, in this study, we examined whether or not IL-10 is involved in the regulation of neutrophil infiltration upon whole-body X-ray irradiation using IL-10 knockout mice. Although IL-10 was induced in the thymus on whole-body X-ray irradiation, apoptosis of thymocytes, neutrophil infiltration, and MIP-2 and KC production in the thymus were not affected by an IL-10 deficiency. Coculturing of bone marrow-derived macrophages with late apoptotic cells caused MIP-2 production, which was also not affected by an IL-10 deficiency. These results suggest the uniqueness of the inflammatory response induced by whole-body X-ray irradiation, which does not seem to be regulated by IL-10. |
