| Primary Identifier | MGI:894315 | Organism | mouse, laboratory |
| Chromosome | 10 | NCBI Gene Number | 215449 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables G protein activity. Involved in modification of postsynaptic structure. Acts upstream of or within several processes, including negative regulation of regulated secretory pathway; positive regulation of ERK1 and ERK2 cascade; and small GTPase-mediated signal transduction. Is active in glutamatergic synapse. Is expressed in brain and eye. Human ortholog(s) of this gene implicated in thrombocytopenia. Orthologous to several human genes including RAP1B (RAP1B, member of RAS oncogene family). PHENOTYPE: Homozygous null mice display partial embryonic and perinatal lethality, abdominal, cranial, and hepatic bleeding in mice that die in utero, reduced platelet aggregation, and decreased thrombus formation. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
