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Publication : Identification and chromosomal localization of Atm, the mouse homolog of the ataxia-telangiectasia gene.

First Author  Pecker I Year  1996
Journal  Genomics Volume  35
Issue  1 Pages  39-45
PubMed ID  8661102 Mgi Jnum  J:33931
Mgi Id  MGI:81411 Doi  10.1006/geno.1996.0320
Citation  Pecker I, et al. (1996) Identification and chromosomal localization of Atm, the mouse homolog of the ataxia-telangiectasia gene. Genomics 35(1):39-45
abstractText  Atm, the mouse homolog of the human ATM gene defective in ataxia-telangiectasia (A-T), has been identified. The entire coding sequence of the Atm transcript was cloned and found to contain an open reading frame encoding a protein of 3066 amino acids with 84% overall identity and 91% similarity to the human ATM protein. Variable levels of expression of Atm were observed in different tissues. Fluorescence in situ hybridization and linkage analysis located the Atm gene on mouse chromosome 9, band 9C, in a region homologous to the ATM region on human chromosome 11q22-q23.
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