| First Author | MacDonald AS | Year | 2002 |
| Journal | J Immunol | Volume | 168 |
| Issue | 2 | Pages | 537-40 |
| PubMed ID | 11777943 | Mgi Jnum | J:126050 |
| Mgi Id | MGI:3760456 | Doi | 10.4049/jimmunol.168.2.537 |
| Citation | MacDonald AS, et al. (2002) Cutting edge: Th2 response induction by dendritic cells: a role for CD40. J Immunol 168(2):537-40 |
| abstractText | We investigated the influence of dendritic cell (DC) CD40 expression on Th2 and Th1 development by in vivo transfer of Ag-pulsed bone marrow-derived DC generated from wild-type (WT) or CD40(-/-) mice. Contrary to expectation, CD40(-/-) DC primed with Ag that inherently induce a Th2 response (soluble egg Ag from Schistosoma mansoni) failed to induce a Th2 response or any compensatory Th1 response, whereas CD40(-/-)DC primed with Ag that inherently induce a Th1 response (Propionibacterium acnes) generated a competent Th1 response. Thus, DC expression of CD40 is a prerequisite for initiation of Th2, but not Th1, responses by these Ag. Consistent with this, CD154(-/-) mice, unlike WT mice, failed to mount a Th2 response when directly injected with schistosome eggs but mounted a normal Th1 response after challenge with P. acnes. CD40-CD154 interaction can therefore play a major role in Th2 response induction. |
