| First Author | Riese RJ | Year | 2001 |
| Journal | Immunity | Volume | 15 |
| Issue | 6 | Pages | 909-19 |
| PubMed ID | 11754813 | Mgi Jnum | J:110511 |
| Mgi Id | MGI:3640433 | Doi | 10.1016/s1074-7613(01)00247-3 |
| Citation | Riese RJ, et al. (2001) Regulation of CD1 function and NK1.1(+) T cell selection and maturation by cathepsin S. Immunity 15(6):909-19 |
| abstractText | NK1.1(+) T cells develop and function through interactions with cell surface CD1 complexes. In I-A(b) mice lacking the invariant chain (Ii) processing enzyme, cathepsin S, NK1.1(+) T cell selection and function are impaired. In vitro, thymic dendritic cells (DCs) from cathepsin S(-/-) mice exhibit defective presentation of the CD1-restricted antigen, alpha-galactosylceramide (alpha-GalCer). CD1 dysfunction is secondary to defective trafficking of CD1, which colocalizes with Ii fragments and accumulates within endocytic compartments of cathepsin S(-/-) DCs. I-A(k), cathepsin S(-/-) mice do not accumulate class II-associated Ii fragments and accordingly do not display CD1 abnormalities. Thus, function of CD1 is critically linked to processing of Ii, revealing MHC class II haplotype and cathepsin S activity as regulators of NK T cells. |
