| Primary Identifier | MGI:1929069 | Organism | mouse, laboratory |
| Chromosome | 17 | NCBI Gene Number | 58230 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Enables histone binding activity and ubiquitin protein ligase activity. Involved in DNA metabolic process; signal transduction in response to DNA damage; and sperm DNA condensation. Located in chromosome, telomeric region; cytoplasm; and nucleus. Is expressed in central nervous system; genitourinary system; nasal cavity epithelium; and thymus primordium. Orthologous to human RNF8 (ring finger protein 8). PHENOTYPE: Homozygous null mice are runted and display premature death, immune organ hypocellularity, reduced male fertility, impaired spermatogenesis, increased sensitivity to gamma-irradiation, increased chromosome breakage and tumor incidence, and a gene dose-dependent defect in class switch recombination. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
