| First Author | Lee SW | Year | 2015 |
| Journal | Biochem Biophys Res Commun | Volume | 461 |
| Issue | 1 | Pages | 86-94 |
| PubMed ID | 25858316 | Mgi Jnum | J:228244 |
| Mgi Id | MGI:5705706 | Doi | 10.1016/j.bbrc.2015.03.174 |
| Citation | Lee SW, et al. (2015) IL32gamma activates natural killer receptor-expressing innate immune cells to produce IFNgamma via dendritic cell-derived IL12. Biochem Biophys Res Commun 461(1):86-94 |
| abstractText | The inflammatory cytokine IL32gamma acts on dendritic cells (DCs) to produce IL12 and IL6, which are involved in the differentiation of Th1 and Th17 cells. Natural killer (NK) and NKT cells play important roles in IL12-mediated adaptive immune responses, such as antitumor immunity. Herein we demonstrate the effect of IL32gamma on the activation of NK and NKT cells. Upon IL32gamma stimulation, splenic NK and NKT cells could be activated, and this activation was dependent on both IL12 and DCs, which was confirmed by using IL12p35 knockout and CD11c-diphtheria toxin receptor transgenic mouse models. Furthermore, IL32gamma could induce the production of proinflammatory cytokines by NKDCs, a subset of DCs expressing NK cell markers, known to enhance NKT cell function. Unlike conventional DCs, NKDCs produced IFNgamma and TNFalpha rather than IL12 upon stimulation with IL32gamma. Taken together, IL32gamma will be useful as an adjuvant to boost the cytotoxicities of NK and NKT cells that play critical roles in antitumor immunity. |
